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Membrane Hyperpolarization Drives Cation Influx and Fungicidal Activity of Amiodarone
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SYSNO ASEP 0323535 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Membrane Hyperpolarization Drives Cation Influx and Fungicidal Activity of Amiodarone Title Hyperpolarizace membrány je příčinou vniku kationtů a antifungální aktivity amiodaronu Author(s) Marešová, Lydie (FGU-C)
Muend, S. (US)
Zhang, Y.Q. (US)
Sychrová, Hana (FGU-C) RID, ORCID
Rao, R. (US)Source Title Journal of Biological Chemistry. - : Elsevier - ISSN 0021-9258
Roč. 284, č. 5 (2009), s. 2795-2802Number of pages 8 s. Language eng - English Country US - United States Keywords membrane potential ; S. cerevisiae ; cation fluxes Subject RIV EB - Genetics ; Molecular Biology R&D Projects LC531 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) KJB500110701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000262700900022 DOI 10.1074/jbc.M806693200 Annotation Amiodarone, an ion channel blocker in clinical use as an antiarrhythmic agent, exhibits broad range fungicidal effects. We show that a polarized membrane is critical for drug toxicity; furthermore, the change in membrane potential precedes and is closely coupled to both cation influx and cell death Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2009
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