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SOI optical microring resonator with poly(ethylene glycol) polymer brush for label-free biosensor applications

SYSNO ASEP	0323474
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	SOI optical microring resonator with poly(ethylene glycol) polymer brush for label-free biosensor applications
Title	SOI mikrokroužkový rezonátor pokrytý kartáčem poly(ethylen oxidu) pro biosenzorové aplikace neznačených analytů
Author(s)	De Vos, D. (BE) Girones, J. (BE) Popelka, Štěpán (UMCH-V)_RID Schacht, E. H. (BE) Baets, R. (BE) Bienstman, P. (BE)
Source Title	Biosensors and Bioelectronics. - : Elsevier - ISSN 0956-5663 Roč. 24, č. 8 (2009), s. 2528-2533
Number of pages	6 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	silicon-on-insulator ; microring resonator ; optical biosensor
Subject RIV	CD - Macromolecular Chemistry
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
UT WOS	000265811000036
DOI	10.1016/j.bios.2009.01.009
Annotation	We report the chemical coating procedure, the chemical surface characterization and optical measurements for both specific and non-specific interactions. Two heterobifunctional polymer coatings were investigated, .alpha.-sulfanyl-.omega.-carboxy-poly(ethylene glycol) and monoprotected diamino-poly(ethylene glycol). The polymer coated sensor with covalently bound biotin receptor molecules showed very low response to Bovine Serum Albumin (BSA) up to 1 mg/ml in contrast to a high response to avidin with much lower concentrations (2, 10, 87.5 and 175 .mu.g/ml). This makes the optical biosensor chip suitable to be integrated in a microflow system for commercial label-free biosensors and for lab-on-a-chip applications.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2009

Number of the records: 1