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Vliv endokrinních disruptorů na reprodukci savců
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SYSNO ASEP 0323303 Document Type K - Proceedings Paper (Czech conf.) R&D Document Type The record was not marked in the RIV Title Vliv endokrinních disruptorů na reprodukci savců Title Effect of endocrine disruptors on mammalian fertility Author(s) Pěknicová, Jana (BTO-N) RID
Nováková, Vendula (BTO-N)
Buckiová, Daniela (UEM-P)
Boubelík, Michael (UMG-J)
Elzeinová, Fatima (BTO-N) RID
Kubátová, Alena (BTO-N) RIDSource Title Alergie. - Praha : Tigis, 2008 - ISSN 1212-3536
S. 47Number of pages 1 s. Action Sjezd českých a slovenských alergologů a klinických imunologů /25./ a Kongres českých a slovenských imunologů s mezinárodní účastí /12./ Event date 29.10.2008-1.11.2008 VEvent location Praha Country CZ - Czech Republic Event type EUR Language cze - Czech Country CZ - Czech Republic Keywords endocrine disruptor ; xenoestrogen ; phytoestrogen ; sperm integrity Subject RIV DN - Health Impact of the Environment Quality R&D Projects 1M06011 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) OKDEQ OE211 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 2B06151 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520701 - BTO-N (2007-2013) AV0Z50390703 - UEM-P (2007-2013) AV0Z50520701 - BTO-N (2007-2013) Description in English Endocrine system is one of the most important regulatory systems in the mammalian body. The endocrine disruptors (ED) can disrupt the function of the endocrine system but their activity is not a result of the physiological regulation. The effect of low dose of selected ED, bisphenol-A (BPA), p-nonylphenol (NP), diethylstilbestrol (DES), genistein (GEN), resveratrol (RES)), hormone (17α-ethynylestradiol (EE2)) and polybrominated compound (tetrabromobisphenol A (TBBPA)) within development of reproductive tract in outbred CD1 mice was tested. BPA and NP had a negative effect on reproductive organs morphology and mouse spermatozoa. The fertility of mice exposed to DES was disrupted. Contrary to that, treatment by GEN and RES had no effect on the fertility of mice but had some effect on their reproductive parameters except for sperm integrity. Synthetic hormone (EE2) and polybrominated compound (TBBPA) also affected on the organ weight, reproductive parameters and sperm quality. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2011
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