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Effect of endocrine disruptors on mammalian fertlity
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SYSNO ASEP 0323287 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Effect of endocrine disruptors on mammalian fertlity Author(s) Pěknicová, Jana (BTO-N) RID
Nováková, Vendula (BTO-N)
Buckiová, Daniela (UEM-P)
Boubelík, Michael (UMG-J)Number of authors 4 Source Title Book of abstract. - Moskva : Medi Expo, 2008 - ISBN 978-5-94943-043-9 Pages s. 60-61 Number of pages 2 s. Action European Congress of Reproductive Immunology /6./ Event date 30.06.2008-03.07.2008 VEvent location Moskva Country RU - Russian Federation Event type WRD Language eng - English Country RU - Russian Federation Keywords endocrine disruptor ; mammalian fertility ; spermatozoa Subject RIV DN - Health Impact of the Environment Quality R&D Projects 1M06011 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 2B06151 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) OE 211 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520701 - BTO-N (2007-2013) AV0Z5039906 - UEM-P AV0Z5052915 - UMG-J Annotation Endocrine system is one of the most important regulatory systems in the mammalian body. The endocrine disruptors (ED) can disrupt the function of the endocrine system but their activity is not a result of the physiological regulation. The effect of low dose of selected ED, bisphenol-A (BPA), p-nonylphenol (NP), diethylstilbestrol (DES), genistein (GEN), resveratrol (RES)), hormone (17α-ethynylestradiol (EE2)) and polybrominated compound (tetrabromobisphenol A (TBBPA)) within development of reproductive tract in outbred CD1 mice was tested. BPA and NP had a negative effect on reproductive organs morphology and mouse spermatozoa. The fertility of mice exposed to DES was disrupted. Contrary to that, treatment by GEN and RES had no effect on the fertility of mice but had some effect on their reproductive parameters except for sperm integrity. Synthetic hormone (EE2) and polybrominated compound (TBBPA) also affected on the organ weight, reproductive parameters and sperm quality. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2011
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