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Coating of adenovirus type 5 with polymers containing quaternary amines prevents binding to blood components

SYSNO ASEP	0322974
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Coating of adenovirus type 5 with polymers containing quaternary amines prevents binding to blood components
Title	Povrchová modifikace adenoviru typu 5 polymery obsahujícími kvarterní amoniové skupiny zabraňuje jejich interakci s krevními komponentami
Author(s)	Šubr, Vladimír (UMCH-V)_{RID, ORCID} Kostka, Libor (UMCH-V)_{RID, ORCID} Selby-Milic, T. (GB) Fisher, K. (GB) Ulbrich, Karel (UMCH-V)_RID Seymour, W. (GB) Carlisle, R. C. (GB)
Number of authors	7
Source Title	Journal of Controlled Release. - : Elsevier - ISSN 0168-3659 Roč. 135, č. 2 (2009), s. 152-158
Number of pages	7 s.
Language	eng - English
Country	NL - Netherlands
Keywords	quaternary ammonium ; HPMA ; adenovirus
Subject RIV	CD - Macromolecular Chemistry
R&D Projects	KJB400500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
UT WOS	000265503900008
DOI	10.1016/j.conrel.2008.12.009
Annotation	Adenovirus type 5 (Ad5) gene therapy vectors require protection against antibodies, complement proteins and blood cells if they are to be delivered intravenously to treat metastatic disease. Such protection can be achieved by chemically modifying Ad5 with polymers based on hydrophilic HPMA. Here, such polymers were designed to include side chains bearing reactive carbonyl thiazolidine-2-thione groups (TTs) to covalently modify available amino groups of the lysine residues in the Ad5 capsid. These data indicate that coating Ad5 therapeutics with such polymers will improve blood circulation half-life and deposition at disease sites.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2009

Number of the records: 1