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Premature processing of mouse mammary tumar virus Gag polyprotein impairs intracellular capsid assembly

SYSNO ASEP	0322918
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Premature processing of mouse mammary tumar virus Gag polyprotein impairs intracellular capsid assembly
Title	Předčasné štěpení Gag polyproteinu viru myšího tumoru prsní žlázy MMTV negativně ovlivňuje intracelulární tvorbu virionu
Author(s)	Zábranský, Aleš (UOCHB-X)_{RID, ORCID} Hadravová, Romana (UOCHB-X)_{RID, ORCID} Štokrová, Jitka (UOCHB-X) Sakalian, M. (US) Pichová, Iva (UOCHB-X)_{RID, ORCID}
Number of authors	5
Source Title	Virology. - : Elsevier - ISSN 0042-6822 Roč. 384, č. 1 (2009), s. 33-37
Number of pages	5 s.
Language	eng - English
Country	US - United States
Keywords	MMTV ; betaretrovirus ; Gag ; Assembly
Subject RIV	CE - Biochemistry
R&D Projects	KJB400550517 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000263039200007
DOI	10.1016/j.virol.2008.10.038
Annotation	We described an unusual intracellular processing of the mouse mammary tumor virus (MMTV) Gag polyprotein in human cells transiently expressing MMTV. The same specific cleavage products of the viral protease were seen for the wild type as well as for nonmyristylated mutant of MMTV Gag polyprotein defective in the particle release. Inactivation of the viral protease resulted in more stable Gag polyprotein and in accumulation of intracytoplasmic particles for nonmyristylated Gag. Our data indicates that protease activation in betaretrovirus can occur independently of budding.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2009

Number of the records: 1