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Synthesis of analogues of acyclic nucleoside diphosphates containing a (phosphonomethyl)phosphanyl moiety and studies of their phosphorylation
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SYSNO ASEP 0322874 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis of analogues of acyclic nucleoside diphosphates containing a (phosphonomethyl)phosphanyl moiety and studies of their phosphorylation Title Syntéza analogů acyklických difosfátů nukleosidů obsahující (fosfonomethyl)fosfonylovou skupinu a studie jejich fosforylace Author(s) Doláková, Petra (UOCHB-X)
Dračínský, Martin (UOCHB-X) RID, ORCID
Fanfrlík, Jindřich (UOCHB-X) RID, ORCID
Holý, Antonín (UOCHB-X)Number of authors 4 Source Title European Journal of Organic Chemistry - ISSN 1434-193X
-, č. 7 (2009), s. 1082-1092Number of pages 11 s. Language eng - English Country DE - Germany Keywords antiviral agents ; nucleotides ; phosphorylation ; dUTPase Subject RIV CC - Organic Chemistry R&D Projects 1QS400550501 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000264045500016 DOI 10.1002/ejoc.200800911 Annotation Stable acyclic nucleoside diphosphate analogues bearing the (phosphonomethyl)phosphinyl moiety were prepared by alkylation of suitably protected heterocyclic bases by alcohols bearing the (phosphonomethyl)phosphinyl unit. Studies of phosphorylation reaction of diphosphonate derivatives showed that both phosphonate and phosphinate moiety react with CDI and tri-n-butylammonium phosphate to give mixture of linear and branched phosphate. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2009
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