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Organization of human replicon: singles or zipping couples?
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SYSNO ASEP 0322349 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Organization of human replicon: singles or zipping couples? Title Organizace lidského replikonu: jednotlivci nebo páry s funkcí molekulárního zipu? Author(s) Ligasová, Anna (UEM-P)
Raška, Ivan (FGU-C)
Koberna, Karel (UEM-P)Source Title Journal of Structural Biology. - : Elsevier - ISSN 1047-8477
Roč. 165, č. 3 (2009), s. 204-213Number of pages 10 s. Language eng - English Country US - United States Keywords Chromatin ; Replication ; Replisomes Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA304/05/0374 GA ČR - Czech Science Foundation (CSF) GA204/07/0133 GA ČR - Czech Science Foundation (CSF) KJB500390701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KAN200520801 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50390512 - UEM-P (2005-2011) AV0Z50110509 - FGU-C (2005-2011) UT WOS 000263422300010 DOI doi:10.1016/j.jsb.2008.11.004 Annotation The comparative analysis showed that replisomes in HeLa cells are organized into the couples during DNA replication. Moreover, our data enabled to suggest a new model of the organization of replicated DNA. According to this model, replisome couples produce a loop with the associated arms in the form of four tightly associated 30 nm fibers. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2009
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