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Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1
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SYSNO ASEP 0322079 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1 Title Lidské erytrocyty obsahující Coxsakie virus-adenovirus receptor a komplement receptor 1 váží a inaktivují adenovirus typu 5 Author(s) Carlisle, R. C. (GB)
Di, Y. (GB)
Cerny, A. M. (US)
Sonnen, A. F. P. (GB)
Sim, R. B. (GB)
Green, N. K. (GB)
Šubr, Vladimír (UMCH-V) RID, ORCID
Ulbrich, Karel (UMCH-V) RID
Gilbert, R. J. C. (GB)
Fisher, K. D. (GB)
Finberg, R. W. (US)
Seymour, L. W. (GB)Source Title Blood. - : American Society of Hematology - ISSN 0006-4971
Roč. 113, č. 9 (2009), s. 1909-1918Number of pages 10 s. Language eng - English Country US - United States Keywords adenovirus ; erythrocyte ; complement receptor 1 Subject RIV CD - Macromolecular Chemistry CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000263723700008 DOI 10.1182/blood-2008-09-178459 Annotation Here we report the unexpected presence of high affinity Ad5 receptors on human erythrocytes, which may function as decoys to protect organism against systemic virus infection, perhaps representing an evolutionary response to the challenge of widespread adenovirus pathology. Here we define the mechanism of Ad5 binding to human erythrocytes and document presentation of Coxsackie virus-adenovirus receptor (CAR) and complement receptor 1 (CR1), which efficiently sequester Ad5 in the absence and presence of anti-Ad5 antibodies, respectively. We demonstrate that erythrocyte binding alters the blood circulation profile of intravenously administered Ad5 and dramatically reduces its extravasation and infectivity. "Stealthing" of Ad5 using hydrophilic polymers may enable circumvention of these natural virus traps. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2009
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