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CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells
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SYSNO ASEP 0321126 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells Title CXXC5, protein regulovaný BMP4, je nový modulátor Wnt signalizace v neurálních kmenových buňkách Author(s) Andersson, T. (SE)
Södersten, E. (SE)
Duckworth, J.K. (SE)
Cascante, A. (SE)
Fritz, N. (SE)
Sacchetti, P. (SE)
Červenka, I. (CZ)
Bryja, Vítězslav (BFU-R) RID, ORCID
Hermanson, O. (SE)Source Title Journal of Biological Chemistry. - : Elsevier - ISSN 0021-9258
Roč. 284, č. 6 (2008), s. 3672-3681Number of pages 10 s. Language eng - English Country US - United States Keywords Wnt signaling ; CXXC5 ; neural stem cells Subject RIV BO - Biophysics CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000262872500035 DOI 10.1074/jbcM808119200 Annotation In a screen designed to identify novel targets of BMP4 signaling in telencephalic neural stem cells we found that the levels of the previously uncharacterized factor CXXC5 were reproducibly upregulated after BMP4 stimulation. We demonstrate that CXXC5 can interact with the Wnt-signaling intermediate. Dishevelled and attenuate Wnt signaling. We conclude that CXXC5 is a BMP4 induced inhibitor of Wnt signaling in neural progenitors. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2009
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