Number of the records: 1

Activation of insect anti-oxidative mechanism by mammalian glucagon

SYSNO ASEP	0321112
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Activation of insect anti-oxidative mechanism by mammalian glucagon
Title	Aktivace hmyzích antioxidačních mechanismů savčím glukagonem
Author(s)	Alquicer, Glenda (BC-A) Kodrík, Dalibor (BC-A)_{RID, ORCID} Krishnan, N. (US) Večeřa, Josef (BC-A) Socha, Radomír (BC-A)
Number of authors	5
Source Title	Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology. - : Elsevier - ISSN 1096-4959 Roč. 152, č. 3 (2009), s. 226-233
Number of pages	8 s.
Language	eng - English
Country	US - United States
Keywords	adipokinetic hormone ; antioxidant capacity ; glucagon
Subject RIV	ED - Physiology
R&D Projects	GA522/07/0788 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50070508 - ENTU-I, BC-A (2005-2011)
UT WOS	000263817500004
DOI	10.1016/j.cbpb.2008.11.007
Annotation	The effect of glucagon was evaluated in an insect model species, the firebug Pyrrhocoris apterus. Using the mouse anti-glucagon antibody, presence of immunoreactive material was demonstrated for the first time in the firebug CNS and gut by ELISA. Mammalian glucagon elicited the antioxidant response by increasing glutathione and decreasing protein carbonyl levels in hemolymph, decreasing both protein carbonyl and protein nitrotyrosine levels in CNS. Additionally, when co-injected with paraquat, glucagon partially eliminated oxidative stress markers elicited by this redox cycling agent and oxidative stressor. This indicates that glucagon might induce an antioxidant defense in insects, as recently described for adipokinetic hormone.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2009

Number of the records: 1