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End-labeling of peptide nucleic acid with osmium complex. Voltammetry at carbon and mercury electrodes

SYSNO ASEP	0320859
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	End-labeling of peptide nucleic acid with osmium complex. Voltammetry at carbon and mercury electrodes
Title	Koncové označení peptidových nukleových kyselin komplexy osmia. Voltametrie na uhlíkových a rtuťových elektrodách
Author(s)	Paleček, Emil (BFU-R)_{RID, ORCID} Trefulka, Mojmír (BFU-R)_{RID, ORCID} Fojta, Miroslav (BFU-R)_{RID, ORCID}
Source Title	Electrochemistry Communications. - : Elsevier - ISSN 1388-2481 Roč. 11, č. 2 (2009), s. 359-362
Number of pages	4 s.
Language	eng - English
Country	US - United States
Keywords	peptide nucleic acid end-labeling ; osmium tetroxide complexes ; electroactive labels
Subject RIV	BO - Biophysics
R&D Projects	KAN400310651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	LC06035 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000263455600031
DOI	10.1016/j.elecom.2008.11.049
Annotation	Peptide nucleic acid (PNA), the DNA mimic with electrically neutral pseudopeptide backbone, is intensively used in biotechnologies and particularly in single-base mismatch detection in DNA hybridization sensors. We propose a simple method of covalent end-labeling of PNA with osmium tetroxide, 2,2'-bipyridine (Os,bipy). Os,bipy-modified PNA (PNA-Os,bipy) produces voltammetric stripping peaks at carbon and mercury electrodes.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2009

Number of the records: 1