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Differential calcium signalling in neuronal-glial networks
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SYSNO ASEP 0319687 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Differential calcium signalling in neuronal-glial networks Title Rozdílný přenos signálů pomocí Ca2+ v neuronálně-gliálních sítích Author(s) Verkhratsky, Alexei (UEM-P)
Anděrová, Miroslava (UEM-P) RID, ORCID
Chvátal, Alexandr (UEM-P) RIDSource Title Frontiers in Bioscience. - : Frontiers Media - ISSN 1093-9946
Roč. 14, č. 1 (2009), s. 2004-2016Number of pages 13 s. Language eng - English Country US - United States Keywords Glial-neuronal ; Calcium signalling ; Nervous system Subject RIV FH - Neurology R&D Projects GA305/06/1316 GA ČR - Czech Science Foundation (CSF) GA305/06/1464 GA ČR - Czech Science Foundation (CSF) 1M0538 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000262352400132 Annotation In the nervous system Ca2+ signalling is intimately involved in information transfer and integration within neural circuits. Local Ca2+ signals or Ca2+ microdomains control neurotransmitter release; more global Ca2+ signals regulate synaptic strength and accomplish postsynaptic processing. In the glial syncytium Ca2+ ions provide for glial "Ca2+ excitability", convey long-range signalling by means of propagating Ca2+ waves and control the release of gliotransmitters. Differential Ca2+ signals in various elements of neural circuits represent therefore molecular mechanisms of integration in the nervous system. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2009
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