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Quantification of astrocyte volume changes during ischemia in situ reveals two populations of astrocytes in the cortex of GFAP/EGFP mice
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SYSNO ASEP 0319586 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Quantification of astrocyte volume changes during ischemia in situ reveals two populations of astrocytes in the cortex of GFAP/EGFP mice Title Kvantifikace objemových změn astrocytů v průběhu ischemie in situ odhalila přítomnost dvou skupin astrocytů v kůře GFAP/EGFP myší Author(s) Benešová, Jana (UEM-P)
Hock, Miroslav (FGU-C)
Butenko, Olena (UEM-P)
Prajerová, Iva (UEM-P)
Anděrová, Miroslava (UEM-P) RID, ORCID
Chvátal, Alexandr (UEM-P) RIDSource Title Journal of Neuroscience Research. - : Wiley - ISSN 0360-4012
Roč. 87, č. 1 (2009), s. 96-111Number of pages 16 s. Language eng - English Country US - United States Keywords Indexing terms ; Ischemia ; Volume regulation Subject RIV FH - Neurology R&D Projects GA305/06/1316 GA ČR - Czech Science Foundation (CSF) GA305/06/1464 GA ČR - Czech Science Foundation (CSF) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50390512 - UEM-P (2005-2011) AV0Z50110509 - FGU-C (2005-2011) UT WOS 000262678300011 DOI 10.1002/jnr.21828 Annotation Using 3D confocal microscopy two astrocyte populations differently responding to ischemia were described in the cortex of GFAP/EGFP mice; the first displaying a significant volume increase and the second displaying only a small volume changes during ischemia. Immunohistochemical analysis showed that the diverse expression of Kir4.1 channels and GFAP as well as differences in taurine accumulation might contribute to the distinct ability of astrocytes to regulate their volume. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
Number of the records: 1