Number of the records: 1
FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway
- 1.
SYSNO ASEP 0318974 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway Title FGFR3 reguluje uzavření synchondróz a fúzi osifikačních center pomocí MAP kinázové dráhy Author(s) Matsushita, T. (US)
Wilcox, W.R. (US)
Chan, Y.Y. (US)
Kawanami, A. (US)
Bükülmez, H. (US)
Balmes, G. (US)
Krejčí, Pavel (BFU-R)
Mekikian, P.B. (US)
Otani, K. (JP)
Yamaura, I. (JP)
Warman, M.L. (US)
Givol, D. (IL)
Murakami, S. (US)Source Title Human Molecular Genetics. - : Oxford University Press - ISSN 0964-6906
Roč. 18, č. 2 (2009), s. 227-240Number of pages 14 s. Language eng - English Country GB - United Kingdom Keywords FGFR3 ; achondroplasia ; synchondrosis Subject RIV BO - Biophysics CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000261897500002 DOI 10.1093/hmg/ddn339 Annotation Article describes the effects of FGFR3-MAPK on premature synchondrosis closure in mouse models or patients suffering from Achondroplasia and Thanatophoric dysplasia. It appears that synchondrosis closure is accelerated by pathological FGFR3 signaling which may constitute a major complicating factor in potential treatment of Achondroplasia. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2009
Number of the records: 1