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DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects

SYSNO ASEP	0318550
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	DNA and glutathione interactions in cell-free media of asymmetric platinum(II) complexes cis- and trans-[PtCl2(isopropylamine)(1-methylimidazole)]: relations to their different antitumor effects
Title	Interakce asymetrických komplexů platiny cis- a trans-[PtCl2(isopropylamin)(1-methylimidazol)] s DNA a glutathionem v bezbuněčném prostředí: vztahy k jejich rozdílným protinádorovým účinkům
Author(s)	Suchánková, Tereza (BFU-R)_{RID, ORCID} Vojtíšková, Marie (BFU-R) Reedijk, J. (NL) Brabec, Viktor (BFU-R)_{RID, ORCID} Kašpárková, Jana (BFU-R)_{RID, ORCID}
Source Title	Journal of Biological Inorganic Chemistry. - : Springer - ISSN 0949-8257 Roč. 14, č. 1 (2009), s. 75-87
Number of pages	13 s.
Language	eng - English
Country	US - United States
Keywords	DNA ; platinum ; cancer
Subject RIV	BO - Biophysics
R&D Projects	LC06030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ME08017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	OC08003 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	1QS500040581 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	IAA400040803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	NR8562 GA MZd - Ministry of Health (MZ)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000261342300007
DOI	10.1007/s00775-008-0425-0
Annotation	The global modification of mammalian and plasmid DNAs by the novel platinum compounds cis-[PtCl2(isopropylamine)(1-methylimidazole)] and trans-[PtCl2(isopropylamine)(1-methylimidazole)] and the reactivity of these compounds with reduced glutathione (GSH) were investigated. The results of this work support the hypothesis that platinum drugs that bind to DNA in a fundamentally different manner from that of conventional cisplatin may have altered pharmacological properties.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2009

Number of the records: 1