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The pi-helix formation between Asp(369) and Thr(375) as a key factor in E(1)-E(2) conformational change of Na(+)/K(+)-ATPase
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SYSNO ASEP 0318424 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The pi-helix formation between Asp(369) and Thr(375) as a key factor in E(1)-E(2) conformational change of Na(+)/K(+)-ATPase Title Vznik π-helixu mezi Asp369–Thr375 je klíčový pro E1-E2 konformační změnu Na+/K+-ATPázy Author(s) Tejral, Gracian (UEM-P)
Koláčná, Lucie (UEM-P)
Schoner, W. (DE)
Amler, Evžen (UEM-P) RIDSource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 58, č. 4 (2009), s. 583-589Number of pages 7 s. Language eng - English Country CZ - Czech Republic Keywords computer modeling ; molecular dynamics simulations ; molecular structure Subject RIV BO - Biophysics R&D Projects 1ET400110403 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA500390702 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 2B06130 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA202/09/1151 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390512 - UEM-P (2005-2011) AV0Z50390703 - UEM-P (2007-2013) UT WOS 000270857000014 DOI doi:10.1186/1472-6750-8-70 Annotation H4-H5-loop structure of Na+/K+-ATPase in E1 and E2 conformations was studied by molecular modeling. E1-E2 transition is connected with π-helix formation (Asp369–Thr375) and distance-shortening between the ATP binding and phosphorylation site by 1.22 nm. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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