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A mouse speciation gene encodes a meiotic histone H3 methyltransferase

SYSNO ASEP	0318335
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	A mouse speciation gene encodes a meiotic histone H3 methyltransferase
Title	Myší speciační gen kóduje meiotickou metyl-transferázu histonu H3
Author(s)	Mihola, Ondřej (UMG-J)_{RID, ORCID} Trachtulec, Zdeněk (UMG-J)_{RID, ORCID} Vlček, Čestmír (UMG-J)_RID Schimenti, J.C. (US) Forejt, Jiří (UMG-J)_{RID, ORCID}
Source Title	Science. - : American Association for the Advancement of Science - ISSN 0036-8075 Roč. 323, č. 5912 (2009), s. 373-375
Number of pages	3 s.
Language	eng - English
Country	US - United States
Keywords	hybrid sterility ; histone H3K4 methyltransferase ; Prdm9
Subject RIV	EB - Genetics ; Molecular Biology
CEZ	AV0Z50520514 - UMG-J (2005-2011)
UT WOS	000262481400036
DOI	10.1126/science.1163601
Annotation	Speciation genes restrict gene flow between the incipient species and related taxa. Three decades ago, we mapped a mammalian speciation gene, hybrid sterility 1 (Hst1), in the intersubspecific hybrids of house mouse. Here, we identify this gene as Prdm9, encoding a histone H3 lysine 4 trimethyltransferase. We rescued infertility in male hybrids with bacterial artificial chromosomes carrying Prdm9 from a strain with the “fertility” Hst1f allele. Sterile hybrids display down-regulated microrchidia 2B (Morc2b) and fail to compartmentalize gH2AX into the pachynema sex (XY) body. These defects, seen also in Prdm9-null mutants, are rescued by the Prdm9 transgene. Identification of a vertebrate hybrid sterility gene reveals a role for epigenetics in speciation and opens a window to a hybrid sterility gene network.
Workplace	Institute of Molecular Genetics
Contact	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Year of Publishing	2009

Number of the records: 1