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The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei

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    SYSNO ASEP0318325
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleThe import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei
    TitleImport a funkce rozsivkového a rostlinného frataxinu v mitochondrii Trypanosoma brucei
    Author(s) Long, Shaojun (BC-A)
    Vávrová, Zuzana (BC-A)
    Lukeš, Julius (BC-A) RID
    Number of authors3
    Source TitleMolecular and Biochemical Parasitology. - : Elsevier - ISSN 0166-6851
    Roč. 162, č. 1 (2008), s. 100-104
    Number of pages5 s.
    Languageeng - English
    CountryNL - Netherlands
    Keywordsfrataxin ; mitochondrion ; Trypanosoma ; diatom ; evolutionary conservativeness ; import
    Subject RIVEB - Genetics ; Molecular Biology
    R&D ProjectsIAA500960705 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
    LC07032 GA MŠk - Ministry of Education, Youth and Sports (MEYS)
    2B06129 GA MŠk - Ministry of Education, Youth and Sports (MEYS)
    GA204/06/1558 GA ČR - Czech Science Foundation (CSF)
    CEZAV0Z60220518 - PAU-O, BC-A (2005-2011)
    UT WOS000260547900011
    DOI10.1016/j.molbiopara.2008.08.001
    AnnotationFrataxin is a conserved mitochondrial protein, almost universally present in prokaryotes and eukaryotes, where it is implicated in Fe-S cluster assembly and several other processes. Here we show that frataxins from the diatom Thalassiosira pseudonana and the plant Arabidopsis thaliana are efficiently targeted and processed in the mitochondrion of the evolutionary distant excavate kinetoplastid flagellate Trypanosoma brucei. Moreover, both heterologous frataxins are able to rescue a lethal deficiency for T. brucei frataxin.
    WorkplaceBiology Centre (since 2006)
    ContactDana Hypšová, eje@eje.cz, Tel.: 387 775 214
    Year of Publishing2009
Number of the records: 1