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The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei

SYSNO ASEP	0318325
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei
Title	Import a funkce rozsivkového a rostlinného frataxinu v mitochondrii Trypanosoma brucei
Author(s)	Long, Shaojun (BC-A) Vávrová, Zuzana (BC-A) Lukeš, Julius (BC-A)_{RID, ORCID}
Number of authors	3
Source Title	Molecular and Biochemical Parasitology. - : Elsevier - ISSN 0166-6851 Roč. 162, č. 1 (2008), s. 100-104
Number of pages	5 s.
Language	eng - English
Country	NL - Netherlands
Keywords	frataxin ; mitochondrion ; Trypanosoma ; diatom ; evolutionary conservativeness ; import
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	IAA500960705 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	LC07032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	2B06129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA204/06/1558 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000260547900011
DOI	10.1016/j.molbiopara.2008.08.001
Annotation	Frataxin is a conserved mitochondrial protein, almost universally present in prokaryotes and eukaryotes, where it is implicated in Fe-S cluster assembly and several other processes. Here we show that frataxins from the diatom Thalassiosira pseudonana and the plant Arabidopsis thaliana are efficiently targeted and processed in the mitochondrion of the evolutionary distant excavate kinetoplastid flagellate Trypanosoma brucei. Moreover, both heterologous frataxins are able to rescue a lethal deficiency for T. brucei frataxin.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2009

Number of the records: 1