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HPV 16-associated tumours: IL-12 can repair the absence of cytotoxic and proliferative responses of tumour infiltrating cells after chemotherapy
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SYSNO ASEP 0318305 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title HPV 16-associated tumours: IL-12 can repair the absence of cytotoxic and proliferative responses of tumour infiltrating cells after chemotherapy Title HPV 16-asociované nádory: IL-12 může obnovit cytotoxické a proliferační odpovědi buněk infiltrujících nádor po chemoterapii Author(s) Indrová, Marie (UMG-J) RID
Bieblová, Jana (UMG-J)
Rossowska, J. (PL)
Kuropka, P. (PL)
Pajtasz-Piasecka, E. (PL)
Bubeník, Jan (UMG-J)
Reiniš, Milan (UMG-J) RIDSource Title International Journal of Oncology. - : Spandidos Publications - ISSN 1019-6439
Roč. 34, č. 1 (2009), s. 173-180Number of pages 8 s. Language eng - English Country GR - Greece Keywords HPV 16 ; vaccines ; tumour-infiltrating cells Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA301/06/0774 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000262127000017 Annotation We have examined the effect of IL-12-producing cellular vaccines on the cytotoxicity and proliferative potential of CD45+ tumour-infiltrating cells (TIL) in mice carrying syngeneic, HPV 16-associated tumours after chemotherapy with CBM-4A ifosfamide derivative. The chemotherapy resulted in decrease of the CD4+ and CD8+ TIL, increase of the Gr-1+/CD11b+ TIL, no changes in the infiltration with CD4+/CD25+ Treg TIL, and decrease of the cytolytic and proliferative potential of the CD45+ TIL. Subsequent immunotherapy with the IL-12-producing, genetically modified TC-1 cells increased tumour infiltration with CD8+ and CD4+ cells, decreased the Gr-1+/CD11b+ cells, and increased the cytolytic and proliferative potential of the CD45+ TIL. These findings suggest that peritumoral administration of the IL-12-producing cellular vaccine can restore the cytolytic potential and inhibit immunosuppressive TIL-dependent mechanisms. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2009
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