Number of the records: 1

Polymorphism in hybrid male sterility in wild-derived Mus musculus musculus strains on proximal chromosome 17

SYSNO ASEP	0316413
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Polymorphism in hybrid male sterility in wild-derived Mus musculus musculus strains on proximal chromosome 17
Title	Polymorfismus sterility hybridnich samcu v proximální oblasti chromosomu 17 v liniich odvozenych z divokych populaci Mus musculus musculus
Author(s)	Vyskočilová, Martina (UBO-W) Pražanová, G. (CZ) Piálek, Jaroslav (UBO-W)_{RID, ORCID, SAI}
Number of authors	3
Source Title	Mammalian Genome. - : Springer - ISSN 0938-8990 Roč. 20, č. 2 (2009), s. 83-91
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	hybrid male sterility ; QTL mapping ; polymorphism ; Mus musculus musculus ; Mus musculus domesticus
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	LC06073 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA206/06/0955 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z60930519 - UBO-W (2005-2011)
UT WOS	000263147900003
DOI	10.1007/s00335-008-9164-3
Annotation	The hybrid sterility-1 (Hst1) locus at Chr 17 causes male sterility in crosses between the house mouse subspecies. We derived two strains, STUS and STUF, that produce sterile and fertile males, respectively, in crosses withC57BL mice. To determine the genetic basis underlying male fertility, the (STUSxSTUF)F1females were mated to C57BL/10J males. Sterile males had a significantly smaller epididymis and testes than parental animals, and lacked spermatozoa due to meiotic arrest. The remaining fertile males displayed no deviation from values found in parental individuals. QTL analysis of the progeny revealed strong associations of male’s fitness components with the proximal end of Chr 17, and a significant effect of the central section of Chr X on testes mass. The data suggest that genetic incompatibilities associated with male sterility have evolved independently at the proximal end of Chr 17 and are polymorphic within both M. m. domesticus and M. m. musculus genomes.
Workplace	Institute of Vertebrate Biology
Contact	Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524
Year of Publishing	2009

Number of the records: 1