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Chromosomal aberrations in tire plant workers and interaction with

SYSNO ASEP	0313804
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Chromosomal aberrations in tire plant workers and interaction with
Title	Chromozomální aberace u pracovníků v gumárenském průmysle a interakce s polymorfizmy genů zahrnutých do biotransformace a DNA opravy
Author(s)	Musak, L. (SK) Souček, P. (CZ) Vodičková, Ludmila (UEM-P)_RID Naccarati, Alessio (UEM-P) Halasová, E. (SK) Poláková, Veronika (UEM-P)_RID Slyšková, Jana (UEM-P)_RID Susová, S. (CZ) Buchancová, J. (SK) Šmerhovský, Z. (CZ) Sediková, J. (SK) Klimentová, G. (SK) Osina, O. (SK) Hemminki, K. (DE) Vodička, Pavel (UEM-P)_RID
Source Title	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. - : Elsevier - ISSN 0027-5107 Roč. 641, 1-2 (2008), s. 36-42
Number of pages	7 s.
Language	eng - English
Country	NL - Netherlands
Keywords	Chromosomal aberrations ; Genetic polymorphisms ; DNA repair genes
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	NR8563 GA MZd - Ministry of Health (MZ)
CEZ	AV0Z50390512 - UEM-P (2005-2011)
UT WOS	000256199000005
DOI	10.1016/j.mrfmmm.2008.02.007
Annotation	We evaluated chromosomal aberrations in lymphocytes of 177 workers exposed to xenobiotics in a tire plant and in 172 controls, in relation to their genetic background. Nine polymorphisms in genes encoding biotransformation enzymes and nine polymorphisms in genes involved in main DNA repair pathways were investigated for possible modulation of chromosomal damage. Present results show that exposed individuals in the tire production, who smoke, exhibit higher chromosomal aberrations frequencies, and the extent of chromosomal damage may additionally be modified by relevant polymorphisms.
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2009

Number of the records: 1