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Tooth agenesis: from molecular genetics to molecular dentistry
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SYSNO ASEP 0312887 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Tooth agenesis: from molecular genetics to molecular dentistry Title Ageneze zubů: od molekulární genetiky k molekulární stomatologii Author(s) Matalová, Eva (UZFG-Y) RID
Fleischmannová, Jana (UZFG-Y)
Sharpe, P. T. (GB)
Tucker, A. S. (GB)Source Title Journal of Dental Research. - : Sage - ISSN 0022-0345
Roč. 87, č. 7 (2008), s. 617-623Number of pages 7 s. Language eng - English Country US - United States Keywords tooth agenesis Subject RIV FF - HEENT, Dentistry R&D Projects KJB500450802 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) OC B23.001 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GC524/08/J032 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50450515 - UZFG-Y (2005-2011) UT WOS 000257019800003 Annotation Tooth agenesis may originate from either genetic or environmental factors. Genetic determined hypodontic disorders appear as isolated features or as part of a syndrome. Msx1 Pax9, and Axin2 are involved in nonsyndromic hypodontia, while genes such as Shh, Pitx2, Irf6, and p63 are considered to participate in syndromic genetic disorders which include tooth agenesis. Artificial tooth implants represent a common solution in dentistry to solve tooth loss problems, however, molecular dentistry offers promising solutions for the future. In this paper, the genetic and molecular basis of nonsyndromic and syndromic hypodontia is reviewed and the advantages and disadvantages of tissue engineering in clinical treatment of tooth agenesis are discussed. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2009
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