Number of the records: 1

Leukotrienes and 8-isoprostane in exhaled breath condensate in bronchoprovocation tests with occupational allergens

SYSNO ASEP	0312364
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Leukotrienes and 8-isoprostane in exhaled breath condensate in bronchoprovocation tests with occupational allergens
Title	Leukotrieny a 8-isoprostan v kondenzátu vydechovaného vzduchu u bonchoprovokačního testu s pracovními alergeny
Author(s)	Klusáčková, P. (CZ) Lebedová, J. (CZ) Kačer, P. (CZ) Kuzma, Marek (MBU-M)_{ORCID, RID} Brabec, Marek (UIVT-O)_{RID, SAI, ORCID} Pelclová, D. (CZ) Fenclová, Z. (CZ) Navrátil, Tomáš (UFCH-W)_{RID, ORCID}
Source Title	Prostaglandins Leukotrienes and Essential Fatty Acids. - : Elsevier - ISSN 0952-3278 Roč. 78, 4-5 (2008), s. 281-292
Number of pages	12 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	occupational allergens ; leukotrienes ; 8-isoprostane
Subject RIV	CC - Organic Chemistry
CEZ	AV0Z50200510 - MBU-M (2005-2011)
	AV0Z10300504 - UIVT-O (2005-2011)
	AV0Z40400503 - UFCH-W (2005-2011)
UT WOS	000257596400007
DOI	10.1016/j.plefa.2008.03.006
Annotation	Exhaled breath condensate (EBC) contains many substances, which could help in diagnosis of occupational asthma. The aim of the study is to monitor leukotrienes (LT) and 8-isoprostane from EBC in bronchoprovocation tests with allergens in 47 patients with suspected occupational asthma. Forty-one patients were tested negative. In negative bronchoprovocation tests, no significant differences (P<0.05) were seen between the five measurements during and after the test. In control measurements (without provocation), significant differences were found among four measurements done within 24 h for 8-isoprostane (P=0.0138). The relationship between the log transformed ratios of the EBC parameters and FEV1 was never significant at the 5 level in control measurements, while in negative tests, statistical significance was recorded for LTB4 (P=0.0299) before and 5 h after the test. Six of 47 patients were tested positive
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2009

Number of the records: 1