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Nanometer size wear debris generated from ultra high molecular weight polyethylene in vivo
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SYSNO ASEP 0312258 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Nanometer size wear debris generated from ultra high molecular weight polyethylene in vivo Title Nanometrové částice vznikající z ultra vysokomolekulárního polyethylenu in vivo Author(s) Lapčíková, Monika (UMCH-V) RID
Šlouf, Miroslav (UMCH-V) RID, ORCID
Dybal, Jiří (UMCH-V) RID, ORCID
Zolotarevova, E. (CZ)
Entlicher, G. (CZ)
Pokorný, D. (CZ)
Gallo, J. (CZ)
Sosna, A. (CZ)Source Title Proceedings of 14th European Microscopy Congress EMC 2008. - Berlin : Springer Verlag Berlin Heidelberg, 2008 / Richter S. ; Schwedt A. - ISBN 978-3-540-85225-4 Pages s. 767-768 Number of pages 2 s. Action European Microscopy Congress EMC 2008 /14./ Event date 01.09.2008-05.09.2008 VEvent location Aachen Country DE - Germany Event type WRD Language eng - English Country DE - Germany Keywords ultrahigh molecular weight polyethylene ; nanometer size wear debris ; morphology Subject RIV CD - Macromolecular Chemistry R&D Projects 2B06096 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40500505 - UMCH-V (2005-2011) Annotation Ultra-high molecular weight polyethylene (UHMWPE) has been used as a bearing material in total joint replacements (TJR) for more than forty years. Friction between polymer and metallic/ceramics components of TJR leads to generation of UHMWPE wear particles, which are released from the joint space and cause complex inflammatory reactions leading to aseptic bone loosening. The wear particles have sizes range from submicron to several-millimeters. It is generally accepted that particles below 10 .mu.m exhibit the highest biological activity. The existence of nano-sized particles was proof in a multidirectional pin on plate wear simulator. Our work brings the first proof that nano-sized wear particles are produced also in vivo. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2009
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