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Aurora kinase A controls meiosis I progression in mouse oocytes

SYSNO ASEP	0310725
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Aurora kinase A controls meiosis I progression in mouse oocytes
Title	Úloha Aurora kinasy A během meiosy I u myších oocytů
Author(s)	Šašková, Adéla (UZFG-Y) Šolc, Petr (UZFG-Y)_{RID, ORCID} Baran, V. (SK) Kubelka, Michal (UZFG-Y)_{RID, ORCID} Schultz, R. M. (US) Motlík, Jan (UZFG-Y)_{RID, ORCID}
Source Title	Cell Cycle. - : Taylor & Francis - ISSN 1538-4101 Roč. 7, č. 15 (2008), s. 2368-2376
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	aurora-A ; MTOC ; CDK1
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	GA305/06/1413 GA ČR - Czech Science Foundation (CSF)
	GD204/05/H023 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50450515 - UZFG-Y (2005-2011)
UT WOS	000258829800015
Annotation	Aurora kinase A (AURKA), which is a centrosome-localized serine/threonine kinase crucial for cell cycle control in somatic cells. We report localization and functions of AURKA during meiotic maturation of mouse oocytes as a model system to study the G2 to M transition. Inhibitor studies using Roscovitine (CDK1 inhibitor), LY-294002 (PI3K inhibitor) and SH-6 (PKB inhibitor) reveal that activation of AURKA localized on MTOCs is independent on PI3K-PKB and CDK1 signaling pathways. Overexpression of AURKA leads to formation of an abnormal MI spindle,whereas RNAi-mediated reduction of AURKA interferes with resumption of meiosis and spindle assembly. Results of these experiments indicate that AURKA is a critical MTOC-associated component involved in resumption of meiosis, MTOC multiplication, proper spindle formation and the metaphase I-metaphase II transition.
Workplace	Institute of Animal Physiology and Genetics
Contact	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Year of Publishing	2009

Number of the records: 1