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Oxidants in biology. A question of balance
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SYSNO ASEP 0309795 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Neutrophil-derived oxidants as modulators of polyunsaturated fatty acid metabolism Title Oxidanty produkované neutrofily jako modulátory metabolismu vysoce nenasycených mastných kyselin Author(s) Kubala, Lukáš (BFU-R) RID, ORCID
Lojek, Antonín (BFU-R) RIDNumber of authors 2 Source Title Oxidants in biology. A question of balance. - Heidelberg : Springer, 2008 / Valacchi G. ; Davis P.A. - ISBN 978-1-4020-8398-3 Pages s. 111-128 Number of pages 18 s. Number of copy 500 Number of pages 328 Language eng - English Country DE - Germany Keywords phagocytes ; reactive oxygen species ; inflammation Subject RIV BO - Biophysics R&D Projects GA524/06/1197 GA ČR - Czech Science Foundation (CSF) GA525/06/1196 GA ČR - Czech Science Foundation (CSF) 1QS500040507 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) Annotation This paper is focused on the role of reactive oxygen species produced by neutrophils in the initiation of lipid peroxidation. The oxidation of lipids is considered as a typical hallmark of chronic and acute inflammatory processes. On the other hand the oxidation of biologically active pro-inflammatory lipids could have anti-inflammatory effects and over all contribute to termination of inflammatory process. Therefore, lipid peroxidation mediated by reactive intermediates produced by neutrophils could both potentiate and reduce inflammatory reaction. Necessity of fine balance of these processes can be suggested for proper control of physiological inflammatory response. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2009
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