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Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis
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SYSNO ASEP 0306741 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis Title Aktivace alternativních drah programované buněčné smrti u buněk s defektní apoptózou závislou na kaspázách Author(s) Ondroušková, E. (CZ)
Souček, Karel (BFU-R) RID, ORCID
Horváth, Viktor (BFU-R)
Šmarda, J. (CZ)Source Title Leukemia Research. - : Elsevier - ISSN 0145-2126
Roč. 32, č. 4 (2008), s. 599-609Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords apoptosis ; autophagy ; programmed cell death Subject RIV BO - Biophysics R&D Projects GA204/07/0834 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) Annotation Loss of programmed cell death pathways is one of the features of malignancy that complicate the response of cancer cells to a therapy. We analysed programmed cell death pathways of v-myb-transformed BM2 monoblasts induced by arsenic trioxide, cycloheximide and camptothecin with U937 promonocytes as a reference cell line. We show that induced death of BM2 cells is not executed by caspases but rather by alternative cell death pathways. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2008
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