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Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers

SYSNO ASEP	0305780
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers
Title	Odpověď normálních a nádorových epiteliálních buněk kolonu na působení apoptických induktorů rodiny TNF
Author(s)	Hofmanová, Jiřina (BFU-R)_{RID, ORCID} Vaculová, Alena (BFU-R)_{RID, ORCID} Hýžďalová, Martina (BFU-R)_{RID, ORCID} Kozubík, Alois (BFU-R)_{RID, ORCID}
Source Title	Oncology Reports - ISSN 1021-335X Roč. 19, č. 2 (2008), s. 567-573
Number of pages	7 s.
Language	eng - English
Country	GR - Greece
Keywords	apoptosis ; TNF-related apoptosis inducing ligand ; TNF-alpha
Subject RIV	BO - Biophysics
R&D Projects	GA524/07/1178 GA ČR - Czech Science Foundation (CSF)
	KJB500040508 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
Annotation	Comparing the response of normal (FHC) and cancer (HT-29) colon epithelial cells showed differences expecially in TRAIL-induced apoptosis. Unlike FHC cells, apoptosis in HT-29 cells was potentiated by combination of TRAIL with inhibitor of MEK/ERK pathway U01126. The main difference between cell lines studied was found in the induction of mitochondrial pathway, which confirms its importance for TRAIL-induced apoptosis.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2008

Number of the records: 1