Number of the records: 1

Sensitivity and specificity of the bioassay of estrogenicity in mammary gland and seminal vesicles of male mice

SYSNO ASEP	0213391
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	Sensitivity and specificity of the bioassay of estrogenicity in mammary gland and seminal vesicles of male mice
Author(s)	Škarda, Josef (UZFG-Y)
Source Title	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 51, č. 3 (2002), s. 267-276
Number of pages	10 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	bioassay ; estrogenicity ; mammary gland
Subject RIV	ED - Physiology
R&D Projects	GA523/99/0843 GA ČR - Czech Science Foundation (CSF)
	KSK5020115 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
Annotation	The effects of a combination of estradiol plus progesterone in the mammary gland were mimicked by norethindrone acetate and inhibited by both testosterone and cortisol. Estradiol,progesterone, norethindrone acetate, or testosterone did not affect spleen weight and size of mammary lymph nodes.However, cortisol significantly decreased not only spleen weights but also size of mammary lymph nodes.The results show that simultaneous evaluation of mammary gland growth, seminal vesicles, and spleen weight in the same animal is suitable for bioassay of estrogenicity as well as for detection of androgenic and antiandrogenic activities.
Workplace	Institute of Animal Physiology and Genetics
Contact	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Year of Publishing	2003

Number of the records: 1