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Structural Studies of anti-CA IX Monoclonal Antibody M75 Fab Fragment in Complex with its Epitope Peptide
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SYSNO ASEP 0191698 Document Type K - Proceedings Paper (Czech conf.) R&D Document Type Conference Paper Title Structural Studies of anti-CA IX Monoclonal Antibody M75 Fab Fragment in Complex with its Epitope Peptide Author(s) Mader, Pavel (UMG-J)
Štouračová, Renata (UMG-J)
Brynda, Jiří (UMG-J) RID
Závada, Jan (UMG-J)Issue data 2004 Source Title Materials Structure in Chemistry, Biology, Physics and Technology. - : Czech and Slovak Crystallographic Association - ISSN 1211-5894
s. 62Number of pages 1 s. Action Meeting of the Czech and Slovak structural biologists /3./ Event date 11.03.2004-13.03.2004 VEvent location Nové hrady Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords CAIX ; antibody ; structure Subject RIV CE - Biochemistry R&D Projects GA203/02/0405 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5052915 - UMG-J Annotation CA IX is a cell surface protein that exerts capacity of binding cell surface receptors, and is associated with several types of human carcinomas. Monoclonal antibody M75 recognizes specifically an epitope identified as six repeats of amino acid sequence PGEEDLP, localized in the proteoglycan like domain of CA IX. Structural study of the M75 Fab fragment in complex with its epitope peptide PGEEDLPGEEDL is presented. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2004
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