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Local IFN-gamma therapy of HPV16-associated tumours

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    SYSNO ASEP0191581
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JOstatní články
    TitleLocal IFN-gamma therapy of HPV16-associated tumours
    Author(s) Mikyšková, Romana (UMG-J) RID
    Bieblová, Jana (UMG-J)
    Šímová, Jana (UMG-J) RID
    Indrová, Marie (UMG-J) RID
    Jandlová, Táňa (UMG-J)
    Vonka, V. (CZ)
    Šmahel, M. (CZ)
    Bubeník, Jan (UMG-J)
    Mendoza, Luis (UMG-J)
    Source TitleFolia Biologica - ISSN 0015-5500
    Roč. 49, č. 1 (2003), s. 26-32
    Number of pages7 s.
    Languageeng - English
    CountryCZ - Czech Republic
    KeywordsMHC class I ; IFN-gamma ; HPV16
    Subject RIVFD - Oncology ; Hematology
    R&D ProjectsNC7148 GA MZd - Ministry of Health (MZ)
    NC5900 GA MZd - Ministry of Health (MZ)
    GA301/01/0985 GA ČR - Czech Science Foundation (CSF)
    CEZAV0Z5052915 - UMG-J
    AnnotationThe paper examines whether peritumoral administration of IFN-gamma can inhibit growth of HPV16-associated, MHC class I- MK16 tumour transplanted in syngeneic mice. Treatment of tumour transplants with IFN-gamma was efficient until the tumours reached a palpable size. Treatment of surgically induced minimal residual tumour disease was moderate, reproducible, but statistically insignificant.
    WorkplaceInstitute of Molecular Genetics
    ContactGabriela Marešová, maresova@img.cas.cz, Tel.: 241 063 217
    Year of Publishing2004