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Initiation factor eIF2B not p70 S6 kinase is involved in the activation of the PI-3K signalling pathway induced by the v=src oncogene
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SYSNO ASEP 0191549 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Initiation factor eIF2B not p70 S6 kinase is involved in the activation of the PI-3K signalling pathway induced by the v=src oncogene Title Na aktivaci signální dráhy PI-3K vyvolané onkogenem v-src se podílí iniciační faktor eIF2B, ale ne kináza p70 S6 Author(s) Vojtěchová, Martina (UMG-J) RID
Šloncová, Eva (UMG-J)
Kučerová, Dana (UMG-J)
Jiřička, Jaroslav (UMG-J)
Sovová, Vlasta (UMG-J)
Tuháčková, Zdena (UMG-J)Source Title FEBS Letters. - : Wiley - ISSN 0014-5793
Roč. 543, 1-3 (2003), s. 81-86Number of pages 6 s. Language eng - English Country NL - Netherlands Keywords phosphoinositide 3-kinase signalling pathway ; mRNA translation ; 70 kDa ribosomal protein S6 kinase Subject RIV CE - Biochemistry R&D Projects GV312/96/K205 GA ČR - Czech Science Foundation (CSF) GA301/00/0269 GA ČR - Czech Science Foundation (CSF) NC5428 GA MZd - Ministry of Health (MZ) CEZ AV0Z5052915 - UMG-J Annotation Our data show that in hamster fibroblasts transformed by Rous sarcoma virus (RSV), the phosphoinositide 3'-kinase (PI-3K)/Akt/glycogen synthase kinase 3 antiapoptotic pathway is upregulated and involved in increased protein synthesis through activation of initiation factor eIF2B. Upon inhibition of PI-3K by wortmannin, phosphorylation of 70-kDa ribosomal protein S6 kinase (p70 S6k) and its physiological substrate, ribosomal protein S6, decreased in the non-transformed cells but not in RSV-transformed cells. Thus PI-3K, which is thought to be involved in regulation of p70 S6k, signals to p70 S6k in normal fibroblasts, but it does not appear to be an upstream effector of p70 S6k in fibroblasts transformed by v-src oncogene, suggesting that changes in the PI-3K signalling pathway upstream of p70 S6k are induced by RSV transformation. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2007
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