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Initiation factor eIF2B not p70 S6 kinase is involved in the activation of the PI-3K signalling pathway induced by the v=src oncogene

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    SYSNO ASEP0191549
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JOstatní články
    TitleInitiation factor eIF2B not p70 S6 kinase is involved in the activation of the PI-3K signalling pathway induced by the v=src oncogene
    TitleNa aktivaci signální dráhy PI-3K vyvolané onkogenem v-src se podílí iniciační faktor eIF2B, ale ne kináza p70 S6
    Author(s) Vojtěchová, Martina (UMG-J) RID
    Šloncová, Eva (UMG-J)
    Kučerová, Dana (UMG-J)
    Jiřička, Jaroslav (UMG-J)
    Sovová, Vlasta (UMG-J)
    Tuháčková, Zdena (UMG-J)
    Source TitleFEBS Letters. - : Elsevier - ISSN 0014-5793
    Roč. 543, 1-3 (2003), s. 81-86
    Number of pages6 s.
    Languageeng - English
    CountryNL - Netherlands
    Keywordsphosphoinositide 3-kinase signalling pathway ; mRNA translation ; 70 kDa ribosomal protein S6 kinase
    Subject RIVCE - Biochemistry
    R&D ProjectsGV312/96/K205 GA ČR - Czech Science Foundation (CSF)
    GA301/00/0269 GA ČR - Czech Science Foundation (CSF)
    NC5428 GA MZd - Ministry of Health (MZ)
    CEZAV0Z5052915 - UMG-J
    AnnotationOur data show that in hamster fibroblasts transformed by Rous sarcoma virus (RSV), the phosphoinositide 3'-kinase (PI-3K)/Akt/glycogen synthase kinase 3 antiapoptotic pathway is upregulated and involved in increased protein synthesis through activation of initiation factor eIF2B. Upon inhibition of PI-3K by wortmannin, phosphorylation of 70-kDa ribosomal protein S6 kinase (p70 S6k) and its physiological substrate, ribosomal protein S6, decreased in the non-transformed cells but not in RSV-transformed cells. Thus PI-3K, which is thought to be involved in regulation of p70 S6k, signals to p70 S6k in normal fibroblasts, but it does not appear to be an upstream effector of p70 S6k in fibroblasts transformed by v-src oncogene, suggesting that changes in the PI-3K signalling pathway upstream of p70 S6k are induced by RSV transformation.
    WorkplaceInstitute of Molecular Genetics
    ContactGabriela Marešová, maresova@img.cas.cz, Tel.: 241 063 217
    Year of Publishing2007