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TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors
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SYSNO ASEP 0191428 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors Author(s) Plašilová, M. (CZ)
Živný, J. (CZ)
Jelínek, J. (CZ)
Neuwirtová, R. (CZ)
Čermák, J. (CZ)
Nečas, E. (CZ)
Anděra, Ladislav (UMG-J) RID
Stopka, T. (CZ)Source Title Leukemia. - : Springer - ISSN 0887-6924
Roč. 16, č. 1 (2002), s. 67-73Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords TRAIL ; leukemia ; apoptosis Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA5052001 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA301/99/0350 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5052915 - UMG-J Annotation normal hematopoieticĺ progenitors and stem cells.#LemfeldSusceptibility of primary malignant and normal hematopoietic progenitors to TRAIL-induced apoptosis was studied by clonogenic assays and by their repopulating potential after transplantation into NOD/SCID mice. In .I.E. coli ./I.produced extacellular part of human TRAIL (Aas 95-281) significantly reduced the number of myeloid colonies (CFU-GM) and clusters from patients with AML, CML, and MDS szndromes bud did not inhibited .I.in vitro ./I.and .I.in vivo ./I.growth of normal hematopoietic progenitors and stem cells. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2002
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