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TRAIL/APO2L inhibits myelodysplasia and myeloid leukemia progenitor growth while it does not affect normal progenitors in vitro and normal CD3+ cell repopulation in NOD/SCID mice
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SYSNO ASEP 0191427 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title TRAIL/APO2L inhibits myelodysplasia and myeloid leukemia progenitor growth while it does not affect normal progenitors in vitro and normal CD3+ cell repopulation in NOD/SCID mice Author(s) Plašilová, M. (CZ)
Živný, J. (CZ)
Jelínek, J. (CZ)
Neuwirtová, R. (CZ)
Čermák, J. (CZ)
Nečas, E. (CZ)
Anděra, Ladislav (UMG-J) RID
Stopka, T. (CZ)Source Title Blood - ISSN 0006-4971
Roč. 98, č. 11 (2001), s. 3043Number of pages 1 s. Language eng - English Country US - United States Keywords TRAIL ; leukemia ; apoptosis Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA5052001 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z5052915 - UMG-J Annotation normal hematopoieticĺ progenitors and stem cells.#LemfeldSusceptibility of primary malignant and normal hematopoietic progenitors to TRAIL-induced apoptosis was studied by clonogenic assays and by their repopulating potential after transplantation into NOD/SCID mice. In .I.E. coli ./I.produced extacellular part of human TRAIL (Aas 95-281) significantly reduced the number of myeloid colonies (CFU-GM) and clusters from patients with AML, CML, and MDS szndromes bud did not inhibited .I.in vitro ./I.and .I.in vivo ./I.growth of normal hematopoietic progenitors and stem cells. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2002
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