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Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes
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SYSNO ASEP 0191416 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes Author(s) Kropshofer, H. (CH)
Spindeldreher, S. (CH)
Rohn, T. A. (CH)
Platania, N. (CH)
Grygar, C. (CH)
Daniel, N. (CH)
Wolpl, A. (DE)
Langen, H. (DE)
Hořejší, Václav (UMG-J) RID
Vogt, A. B. (CH)Source Title Nature Immunology. - : Nature Publishing Group - ISSN 1529-2908
Roč. 3, č. 1 (2002), s. 61-68Number of pages 8 s. Language eng - English Country US - United States Keywords MHC II ; tetraspan microdomains ; peptide presentation Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z5052915 - UMG-J Annotation Subsets of MHC class II molecules localize to membrane microdomains together with tetraspan proteins, HLA-DM and the costimulator CD86. Tetraspan microdomains enrich MHC class II molecules carrying a selected set of peptide antigens .Antigen-presenting cells deficient in tetraspan microdomains have a reduced capacity to activate CD4+ T cells. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2002
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