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Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16
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SYSNO ASEP 0191194 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16 Author(s) Šmahel, M. (CZ)
Sobotková, E. (CZ)
Bubeník, Jan (UMG-J)
Šímová, Jana (UMG-J) RID
Žák, R. (CZ)
Ludvíková, V. (CZ)
Mikyšková, Romana (UMG-J) RID
Kovařík, J. (CZ)
Jelínek, F. (CZ)
Povýšil, C. (CZ)
Marinov, J. (CZ)
Vonka, V. (CZ)Source Title British Journal of Cancer. - : Springer - ISSN 0007-0920
Roč. 84, č. 3 (2001), s. 374-380Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords human papillomavirus ; E6/E7 oncogenes ; cell transformation Subject RIV EB - Genetics ; Molecular Biology R&D Projects NC5900 GA MZd - Ministry of Health (MZ) NC5526 GA MZd - Ministry of Health (MZ) GA312/99/0542 GA ČR - Czech Science Foundation (CSF) GA312/98/0826 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5052915 - UMG-J Annotation Mouse cells were transformed with E6/E7 HPV 16 and activatedH-ras oncogenes. An oncogenic cell line, designatedMK16/1/IIIABC, was derived, lacking MHC class I and II molecules on the cell surface and forming metastases in lymph nodes and lungs after prolonged growth of s.c. induced limited protection against challenge with homologous cells. These cells can therefore serve as a model for studying immune reactions against HPV 16-associated tumours. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2002
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