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Nuclear pre-mRNA compartmentalization: Trafficking of released transcripts to splicing factor reservoirs
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SYSNO ASEP 0173343 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Nuclear pre-mRNA compartmentalization: Trafficking of released transcripts to splicing factor reservoirs Author(s) Melčák, Ivo (UEM-P)
Cermanová, Štěpánka (UEM-P)
Jirsová, Kateřina (UEM-P)
Koberna, Karel (UEM-P)
Malínský, Jan (UEM-P) RID, ORCID
Raška, Ivan (UEM-P)Source Title Molecular Biology of the Cell - ISSN 1059-1524
Roč. 11, - (2000), s. 497-510Number of pages 14 s. Language eng - English Country US - United States Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA302/99/0587 GA ČR - Czech Science Foundation (CSF) GA304/00/1481 GA ČR - Czech Science Foundation (CSF) VS96129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z5039906 - UEM-P Annotation In the present study, the spatial organization of intron - containing pre-mRNAs of Epstein - Barr virus (EBV) genes relative to location of splicing factors is investigated. The intranuclear position of transcriptionally active EBV genes, as well as oof nascent transcripts, is found to be randonwith respect to the speckled accumulations of splicing factors (SC35 domains) in Namalwa cells, arguing against the concept of the locus - specific organization of mRNA genes with respect to the speckles. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2001
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