Improvement of the accuracy by the measurement of the electrical cell membrane parameters
1.
SYSNO ASEP
0142309
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Improvement of the accuracy by the measurement of the electrical cell membrane parameters
Author(s)
Rohlíček, Vojtěch (FGU-C) Rech, František (FGU-C)
Source Title
Physiological Research. - : Fyziologický ústav AV ČR, v. v. i.
- ISSN 0862-8408
Roč. 51, č. 2 (2002), s. 169-177
Number of pages
9 s.
Language
eng - English
Country
CZ - Czech Republic
Keywords
patch clamp technique ; electrical parameters of the cell membrane ; memebrane capacity
Subject RIV
BO - Biophysics
CEZ
AV0Z5011922 - FGU-C
Annotation
The electrical parameters of the cell membrane are mostly estimated employing ac methods. The measurement is based on the analysis of the current(s) flowing through an access resistance and the membrane. A current/potential transducer is used at the input of the device. The parameters of this transducer, especially its feedback capacity, degrades the accuracy of the measurement and hence diminishes the suppression of mutual influences of the individual parameters. The paper suggest a possible software correction and is supplemented by remarks for practical application.