Number of the records: 1

Screening of the health risks of biofilms using a battery of in vitro toxicity assays

SYSNO ASEP	0129556
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	Conference Paper
Title	Screening of the health risks of biofilms using a battery of in vitro toxicity assays
Author(s)	Bláha, Luděk (BU-J) Babica, P. (CZ) Sabatier, S. (ES) Admiraal, W. (NP) Maršálek, Blahoslav (BU-J)_{ORCID, SAI}
Source Title	SECOTOX 2002: Trends and advances in environmental chemistry and ecotoxicology. - Brno : Masarykova univerzita, 2002 - ISBN 80-210-2971-4
Pages	s. 150-154
Number of pages	5 s.
Action	Regional Meeting of the Central and Eastern European Section /7./
Event date	14.10.2002-16.10.2002
VEvent location	Brno
Country	CZ - Czech Republic
Event type	EUR
Language	eng - English
Country	CZ - Czech Republic
Keywords	HCPL ; microcystin
Subject RIV	EF - Botanics
R&D Projects	KSK6005114 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z6005908 - BU-J
Annotation	Traces of microcystin-lika compounds were detected by HPCL in biofilm samples from Netherlands. Half of the tested samples had no significant effect in any of the in vitro assays, other biofilms elicicted weak inhibitory/toxic effects mostly in high concentrations, which are not environmentally relevant. Most of observed weak effect seem to be associated with oxidative stress, an important toxicologicalĺmechanisms, as detected by depletion of intracellular antioxidantĺGHS by several biofilm samples. Potential adverse effects ofĺexterne polutants, which are known to accumulate in theĺperyphyton biomass should not underestimated. Mutagenicity andĺneurotoxicity of biofilm metabolits seems to be negligible. Weekĺadverse effects of biofilm extracts detected in a batery of inĺvitro assays indicate relatively low human health risksĺassociated with biofilm toxicity.
Workplace	Institute of Botany
Contact	Martina Bartošová, martina.bartosova@ibot.cas.cz, ibot@ibot.cas.cz, Tel.: 271 015 242 ; Marie Jakšová, marie.jaksova@ibot.cas.cz, Tel.: 384 721 156-8
Year of Publishing	2003

Number of the records: 1