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DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines
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SYSNO ASEP 0126967 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines Author(s) Kašpárková, Jana (BFU-R) RID, ORCID
Marini, Victoria (BFU-R)
Najajreh, Y. (IL)
Gibson, D. (IL)
Brabec, Viktor (BFU-R) RID, ORCIDSource Title Biochemistry. - : American Chemical Society - ISSN 0006-2960
Roč. 42, č. 20 (2003), s. 6321-6332Number of pages 12 s. Language eng - English Country US - United States Keywords cross links ; DNA ; nonclassical platinum complexes Subject RIV BO - Biophysics R&D Projects IAA5004101 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KJB5004301 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA305/01/0418 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5004920 - BFU-R Annotation The global modification of mammalian and plasmid DNAs by novel platinum compounds, cis- or trans-[PtCl2(NH3)(Am)], where Am = NH3, nonplanar heterocycle piperidine, piperazine, or aromatic planar heterocycle 4-picoline, was investigated in cell-free media. These modifications have been compared with the activity of these new compounds in several tumor cell lines. The results show that the replacement of the NH3 group in cisplatin by the heterocyclic ligands does not considerably affect the DNA binding mode of this drug. In contrast to the analogues of cisplatin, the replacement of one ammine group by the heterocyclic ligand in its clinically ineffective trans isomer (transplatin) results in a radical enhancement of its activity in tumor cell lines. This replacement also markedly alters the DNA binding mode of transplatin. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2004
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