Number of the records: 1
Regulation of Cys-based protein tyrosine phosphatases via reactive oxygen and nitrogen species in mast cells and basophils
- 1.
SYSNO ASEP 0116791 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Regulation of Cys-based protein tyrosine phosphatases via reactive oxygen and nitrogen species in mast cells and basophils Title Regulace protein tyrozin fosfatáz založených na Cys prostřednictvím reaktivních forem kyslíku a dusíku v žírných buňkách a bazofilech Author(s) Heneberg, Petr (UMG-J)
Dráber, Petr (UMG-J) RIDSource Title Current Medicinal Chemistry. - : Bentham Science Publishers - ISSN 0929-8673
Roč. 12, č. 16 (2005), s. 1859-1871Number of pages 13 s. Language eng - English Country NL - Netherlands Keywords mast cell ; tyrosine phosphatase ; reactive oxygen species Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA204/03/0594 GA ČR - Czech Science Foundation (CSF) GA301/03/0596 GA ČR - Czech Science Foundation (CSF) IAA5052310 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) NR8079 GA MZd - Ministry of Health (MZ) 1M0506 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1P04OE158 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50520514 - UMG-J (2005-2011) Annotation Activation of mast cells and basophils is accompanied by production of reactive oxygen and nitrogen species that regulate diverse signaling pathways leading to the release of inflammatory mediators and production of diverse cytokines. Although the functional pathways of ROS and RNS in vivo are not completely understood, some novel metabolic pathways can be envisioned based on recent findings that protein tyrosine phosphatases can be regulated by reversible oxidation. In this review, we describe major sources and targets of reactive oxide and nitrogen species in mast cells and basophils. Direct and indirect regulations of class I and II Cys-based protein tyrosine phosphatases (LMW-PTP, PTEN, PTP-PEST, SHP-2, PTP1B, PTPalpha, PTPepsilon, DEP-1, TC45, SHP-1, HePTP and LAR) are discussed. The combined data highlight the role of redox-regulated protein tyrosine phosphatases as targets in the development of new ways of therapeutic intervention in allergies and inflammatory diseases. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2006
Number of the records: 1