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Modulation of the Fcepsilon receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases
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SYSNO ASEP 0109001 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Modulation of the Fcepsilon receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases Title Modulace signalizace receptoru Fcepsilon I inhibitory tyrozin kináz: hledání terapeutických cílů zánětlivých a alergických chorob Author(s) Lusková, Petra (UMG-J)
Dráber, Petr (UMG-J) RIDSource Title Current Pharmaceutical Design - ISSN 1381-6128
Roč. 10, č. 15 (2004), s. 1727-1736Number of pages 10 s. Language eng - English Country NL - Netherlands Keywords mast cell ; Fc receptor ; protein kinase Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA5052310 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA204/03/0594 GA ČR - Czech Science Foundation (CSF) GA310/00/0205 GA ČR - Czech Science Foundation (CSF) GA301/03/0596 GA ČR - Czech Science Foundation (CSF) NB6758 GA MZd - Ministry of Health (MZ) LN00A026 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z5052915 - UMG-J Annotation This review is focused on the use of tyrosine kinase inhibitors specific for Src family kinases (PP1/PP2, SU6656 and CT5269), Syk kinase (piceatannol, ER-27319 and BAY 61-3606) and Btk (terreic acid and LFM-A13) for a modulation of FcepsilonRI-mediated signaling in mast cells. Potential use of the inhibitors in the treatment of inflammatory and allergy diseases as well as future directions in the development of highly specific tyrosine kinases inhibitors of new generations and their use in an intended modulation of mast cell signaling are discussed Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2005
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