MHC class I down-regulation: Tumour escape from immune surveillance? (Review)
1.
SYSNO ASEP
0105304
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
MHC class I down-regulation: Tumour escape from immune surveillance? (Review)
Title
Snížená exprese MHC 1. třídy: únik nádorů z imunitní kontroly?
Author(s)
Bubeník, Jan (UMG-J)
Source Title
International Journal of Oncology. - : Spandidos Publications
- ISSN 1019-6439
Roč. 25, č. 2 (2004), s. 487-491
Number of pages
5 s.
Language
eng - English
Country
GR - Greece
Keywords
MHC class I- tumour cells ; immune surveillance
Subject RIV
EC - Immunology
R&D Projects
NC7148 GA MZd - Ministry of Health (MZ)
GA301/04/0492 GA ČR - Czech Science Foundation (CSF)
IAA5052203 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ
AV0Z5052915 - UMG-J
Annotation
It is suggested that MHC class I down-regulation can, under some conditions, be a mechanism of the tumour escape from the immune defence. The therapeutic procedures aiming at up-regulation of MHC class I expression, or enhancement of MHC class I-unrestricted (CD4+, NK, NKT, gamma-delta T) tumour defence effector mechanisms by dendritic cell-based therapeutic vaccines, by cytokines (IL-2, IL-12, IFNgamma, GM-CSF), or by the cytokine gene-based, genetically modified tumour vaccines should be considered
