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Interactions of hydrated divalent metal cations with nucleic acid bases. How to relate the gas phase data to solution situation and binding selectivity in nucleic acids

SYSNO ASEP	0104703
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	Interactions of hydrated divalent metal cations with nucleic acid bases. How to relate the gas phase data to solution situation and binding selectivity in nucleic acids
Title	Interakce hydratovaných divalentních kovových iontů s bázemi nukleových kyselin. Jak dát do vzájemného vztahu data z plynné fáze, situaci v roztoku a vazebnou selektivitu v nukleových kyselinách
Author(s)	Šponer, Judit E. (UFCH-W) Sychrovský, Vladimír (UFCH-W) Hobza, Pavel (UFCH-W) Šponer, Jiří (UFCH-W)
Source Title	Physical Chemistry Chemical Physics. - : Royal Society of Chemistry - ISSN 1463-9076 Roč. 6, č. 10 (2004), s. 2772-2780
Number of pages	9 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	nucleic acids ; gas phase ; guanine
Subject RIV	BO - Biophysics
R&D Projects	LN00A016 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LN00A032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z5004920 - BFU-R
Annotation	Binding modes of hydrated Zn2+ and Mg2+ cations to the N7 and O6 positions of guanine have been characterized by state-of-the-art ab initio model calculations. We show how differences in the electronic structure of the cationic complexes, as revealed by gas-phase computations, translate into differences in the biological function of the two studied metals.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2005

Number of the records: 1