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Detecting DNA damage with a silver solid amalgam electrode

SYSNO ASEP	0104624
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	Detecting DNA damage with a silver solid amalgam electrode
Title	Detekce poškození DNA pomocí elektrody z pevného stříbrného amalgamu
Author(s)	Kuchaříková, Kateřina (BFU-R) Novotný, Ladislav (UFCH-W) Josypčuk, Bohdan (UFCH-W)_{RID, SAI, ORCID} Fojta, Miroslav (BFU-R)_{RID, ORCID}
Source Title	Electroanalysis. - : Wiley - ISSN 1040-0397 Roč. 16, č. 5 (2004), s. 410-414
Number of pages	5 s.
Language	eng - English
Country	US - United States
Keywords	DNA damage ; silver solid amalgam electrode ; HMDE
Subject RIV	BO - Biophysics
R&D Projects	IAA4004108 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	IBS5004355 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z5004920 - BFU-R
Annotation	Mercury electrodes modified with supercoiled (sc) DNA have been used as highly sensitive tools for the detection of DNA strand breaks or as sensors for DNA cleaving substances. In this paper we show that silver solid amalgam electrode (AgSAE), in connection with alternating current voltammetry, provides similar information about DNA damage as the hanging mercury drop electrode. The AgSAE can be used for the detection of enzymatic or chemical DNA cleavage in solution or at the electrode surface. AgSAE modified with scDNA can be utilized as a sensor for DNA nicking substances.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2005

Number of the records: 1