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Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity
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SYSNO ASEP 0102571 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity Title Thiochrom zvyšuje afinitu pro acetylcholin u muskarinových M4 receptorů: podtypová selektivita na základě kooperativity spíše než afinity Author(s) Lazareno, S. (GB)
Doležal, Vladimír (FGU-C) RID, ORCID
Popham, A. (GB)
Birdsall, N. J. M. (GB)Source Title Molecular Pharmacology - ISSN 0026-895X
Roč. 65, č. 1 (2004), s. 257-266Number of pages 10 s. Language eng - English Country US - United States Keywords muscarinic receptors ; thiochrome ; allosteric effect Subject RIV ED - Physiology R&D Projects GA305/01/0283 GA ČR - Czech Science Foundation (CSF) GA309/02/1331 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5011922 - FGU-C Annotation Thiochrome binds to all muscarinic receptor subtypes but allosterically enhances affinity for acetylcholine only at M4 subtype in both binding and functional assays. These results demonstrate a new absolute form of subtype specificity which is derived from cooperativity rather than from affinity Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2005
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