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Cytogenetic analysis using fluorescence in situ hybridization (FISH) to evaluate occupational exposure to carcinogens

SYSNO ASEP	0100990
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	Cytogenetic analysis using fluorescence in situ hybridization (FISH) to evaluate occupational exposure to carcinogens
Title	Cytogenetická analýza pomocí fluorescence in situ hybridization (FISH) při hodnocení profesionální expozice karcinogenům
Author(s)	Šrám, Radim (UEM-P)_RID Beskid, Olena (UEM-P) Binková, Blanka (UEM-P) Rössner, P. (CZ) Šmerhovský, Zdeněk (UEM-P)
Source Title	Toxicology Letters. - : Elsevier - ISSN 0378-4274 Roč. 149, - (2004), s. 335-344
Number of pages	10 s.
Language	eng - English
Country	IE - Ireland
Keywords	Chromosomal aberrations ; Fluorescence in situ hybridization
Subject RIV	DN - Health Impact of the Environment Quality
R&D Projects	SI/340/2/00 GA MŽP - Ministry of Environment (MŽP)
CEZ	AV0Z5039906 - UEM-P
Annotation	Groups occupationally exposed to 1,3-butadiene (BD), acrylonitrile, ethyl benzene and benzene in petrochemical industry, and carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) from ambient air were followed both by conventional cytogenetic analysis and FISH painting for chromosomes # 1 and # 4, in total 383 subjects, including controls. The findings indicate that the method FISH with whole chromosome painting seems to be more sensitive to detect chromosomal injury by occupational exposure to carcinogens than the conventional method
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2005

Number of the records: 1