Patogenní protein YopP bakterie Yersinia enterocolitica inhibuje příjem antigenů řízený MAP kinázami u dendritických buněk
Author(s)
Autenrieth, S. E. (DE) Adkins, Irena (MBU-M) Rösemann, R. (DE) Gunst, D. (DE) Zahir, N. (DE) Kracht, M. (DE) Ruckdeschel, K. (DE) Wagner, H. (DE) Borgmann, S. (DE) Autenrieth, I. B. (DE)
Source Title
Cellular Microbiology. - : Wiley
- ISSN 1462-5814
Roč. 9, č. 2 (2007), s. 425-437
Yersinia enterocolitica inhibits the ability of dendritic cells (DC) to trigger T cell activation. Here, we investigated if these bacteria might interfere with antigen prezentation in DCs. We found that Yersinia outer protein P (YopP) of Y. enterocolitica inhibits receptor-mediated endocytosis by targeting mitogen-activated protein kinases (MAPK). Moreover, we showed that Y. enterocolitica inhibits macropinocytosis by yet unknown mechanism. All of which contributes to the evasion strategy of adaptive immunity
