Yersinia outer proteins E, H, P, and T differentially target the cytoskeleton and inhibit phagocytic capacity of dendritic cells
1.
SYSNO ASEP
0099298
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Yersinia outer proteins E, H, P, and T differentially target the cytoskeleton and inhibit phagocytic capacity of dendritic cells
Title
Patogenní proteiny Yersinie YopE, YopH, YopP a YopT rozdílně poškozují cytoskelet a inhibují schopnost fagocytózy u dendritických buněk
Author(s)
Adkins, Irena (MBU-M) Köberle, M. (DE) Gröbner, S. (DE) Bohn, E. (DE) Autenrieth, I. B. (DE) Borgmann, S. (DE)
Source Title
International Journal of Medical Microbiology. - : Elsevier
- ISSN 1438-4221
Roč. 297, - (2007), s. 235-244
Number of pages
10 s.
Language
eng - English
Country
DE - Germany
Keywords
yersinia ; yops ; dendritic cells
Subject RIV
EC - Immunology
CEZ
AV0Z50200510 - MBU-M (2005-2011)
Annotation
Yersinia outer proteins (Yops) of Yersinia enterocolitica disrupt the actin cytoskeleton and phagocytosis of epithelial cells and macrophages. Here, we investigated the effects of different Yops of Y. enterocolitica on murine dendritic cells (DC). YopE, YopH and YopT cooperate to rapidly disrupt the actin cytoskeleton of DC, whereas YopE and YopH are the main effector protein responsible for the inhibition of the phagocytic function of DC. We revealed cell type-specific as well as Yersinia strain and serotype-specific effects of Yops on innate immune functions of DC
